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Related Experiment Videos

Transformations of cannabinol in the mouse.

S Burstein, C Varanelli

    Research Communications in Chemical Pathology and Pharmacology
    |July 1, 1975
    PubMed
    Summary

    This study details the in vivo metabolism of cannabinol (CBN) in mice, establishing its metabolic pathway. Findings suggest cannabinol may be a transformation product of delta1-tetrahydrocannabinol (THC).

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    Area of Science:

    • Pharmacology and Toxicology
    • Biochemistry
    • Drug Metabolism

    Background:

    • Cannabinoids, including cannabinol (CBN), undergo metabolic transformations in vivo.
    • Understanding cannabinoid metabolism is crucial for pharmacology and toxicology.
    • Previous studies have identified metabolites of delta1-tetrahydrocannabinol (THC).

    Purpose of the Study:

    • To elucidate the in vivo metabolic pathway of cannabinol (CBN) in a mouse model.
    • To identify and characterize the metabolites of CBN.
    • To investigate the potential relationship between CBN and delta1-tetrahydrocannabinol (THC) metabolism.

    Main Methods:

    • In vivo administration of cannabinol (CBN) to mice.
    • Isolation and identification of CBN metabolites from biological samples.
    • Comparative analysis of CBN metabolites with known delta1-tetrahydrocannabinol (THC) metabolites.

    Main Results:

    • A distinct pattern of CBN metabolism was established in vivo.
    • Hydroxylation at the 7 position and side chain, followed by oxidation to acidic metabolites, was observed.
    • Two identified CBN metabolites were previously found as metabolites of delta1-tetrahydrocannabinol (THC).

    Conclusions:

    • Cannabinol (CBN) undergoes significant hydroxylation and oxidation during metabolism.
    • The presence of shared metabolites suggests that CBN might be a metabolic product of delta1-tetrahydrocannabinol (THC).
    • These findings contribute to understanding the metabolic fate and interconversion of major cannabinoids.

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