A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments
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Updated: Oct 4, 2026
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
Published on: November 1, 2012
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02141, USA.
Abstract:
A matrix screen is presented with optimized conditions for the crystallization of nucleic acid fragments. The screen consists of 24 conditions only and utilizes minimal amounts of sample. It has been tested on a series of DNA and RNA oligomers, and yielded diffraction-quality crystals of many specimens including drug-DNA complexes. Preliminary X-ray analysis of the crystals is reported.
