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Calbindins decreased after space flight.

I N Sergeev1, W B Rhoten, M D Carney

  • 1Department of Anatomy, Cell and Neurobiology, Marshall University School of Medicine, Huntington, WV, USA.

Endocrine
|December 1, 1996
PubMed
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Spaceflight microgravity significantly reduces calbindin-D28k in kidneys and calbindin-D9k in the small intestine. This decrease in vitamin D-dependent calcium-binding proteins may explain space flight-induced calcium metabolism disorders.

Area of Science:

  • Space Biology
  • Cellular Physiology
  • Biochemistry

Background:

  • Space flight alters calcium (Ca2+) metabolism.
  • The mechanisms behind these Ca2+ changes are not fully understood.
  • Calbindins are vitamin D-dependent Ca2+ binding proteins crucial for Ca2+ homeostasis.

Purpose of the Study:

  • To investigate the expression of calbindin-D28k and calbindin-D9k in rat kidneys, small intestine, and pancreas after space flight.
  • To compare microgravity effects with modeled weightlessness.

Main Methods:

  • Biochemical and immunocytochemical analyses were performed on rat tissues.
  • Enzyme-linked immunosorbent assay (ELISA) measured calbindin content.
  • Quantitative computer image analysis assessed in situ calbindin and insulin immunoreactivity.
Keywords:
NASA Discipline Cell BiologyNASA Discipline Number 00-00NASA Program FlightNon-NASA Center

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Main Results:

  • Microgravity exposure significantly decreased calbindin-D28k in kidneys and calbindin-D9k in the small intestine.
  • Modeled weightlessness showed similar reductions in calbindins.
  • No significant changes in pancreatic insulin were observed.

Conclusions:

  • Short-term microgravity exposure reduces calbindin expression in the kidney and small intestine.
  • Decreased calbindin expression may contribute to space flight-associated calcium metabolism disorders.