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Related Experiment Videos

[Paget's deforming osteodysttophy].

P Cottier, W Bandi, C Aegler

    Schweizerische Medizinische Wochenschrift
    |May 31, 1975
    PubMed
    Summary
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    Can bisphosphonates be given to patients with fractures?

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2001

    This review covers Paget's osteodystrophy, detailing its clinical aspects, complications, and diagnostic methods. It highlights successful surgical interventions for fractures and femur deformities, alongside conservative management for pelvic involvement.

    Area of Science:

    • Orthopedics
    • Rheumatology
    • Endocrinology

    Context:

    • Paget's osteodystrophy is a chronic bone disorder with diverse clinical manifestations.
    • Understanding its natural course and complications is crucial for patient management.
    • Recent research highlights potential correlations between disease extent and serum markers.

    Purpose:

    • To review the current clinical aspects of Paget's osteodystrophy.
    • To describe its definition, localization, course, and signs.
    • To discuss diagnostic modalities and therapeutic options.

    Summary:

    • The review details Paget's disease clinical features, including "rheumatoid manifestations" and correlations with alkaline phosphatase and uric acid.
    • Orthopedic, neurological, hemodynamic, oncologic, hematologic, and dermatologic complications are discussed.

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  • Diagnostic tools include X-ray, isotope scanning, and bone biopsy. Current treatments involve diphosphonates and calcitonin; mithramycin's use is limited by toxicity.

    • Impact:

    • Presents successful surgical cases: fracture consolidation and corrective osteotomy for femur deformities.
    • Illustrates conservative management for extensive pelvic Paget's disease in an elderly patient.
    • Provides insights into managing fractures and deformities in Paget's osteodystrophy.