Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heavy ion induced changes in small intestinal parameters.

K E Carr1, J S McCullough, P Brennan

  • 1School of Biomedical Science, The Queen's University of Belfast, Ireland.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|October 1, 1994
PubMed
Summary

Heavy ion radiation, including neon and iron relevant to space flight, affects mouse small intestine structure. Neon ions caused the most damage, indicating complex responses to increasing radiation linear energy transfer (LET).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Botulism, Botulinus Toxin, Byheart Baby Formula: Life-Saving Thoracic Duct Lymph Drainage?

Lymphology·2026
Same author

High hyaluronan binding and RHAMM expression identify an invasive and metastatic subpopulation in androgen-resistant prostate cancer cells.

Matrix biology : journal of the International Society for Matrix Biology·2025
Same author

Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression.

Oncogene·2016
Same author

Hypertension and mortality in the Golestan Cohort Study: A prospective study of 50 000 adults in Iran.

Journal of human hypertension·2015
Same author

Protein pheromone expression levels predict and respond to the formation of social dominance networks.

Journal of evolutionary biology·2015
Same author

The role of imaging in anoxic brain injury and brain death: a review of modalities with an Irish and international perspective.

Irish journal of medical science·2015

Area of Science:

  • Radiation biology
  • Space medicine
  • Gastrointestinal physiology

Background:

  • Space flight exposes astronauts to heavy ion radiation, posing risks to organ systems.
  • Understanding the radiobiological effects of different heavy ions on tissues is crucial for radiation protection.
  • The small intestine is a sensitive organ to radiation damage.

Purpose of the Study:

  • To compare the effects of neon, iron, and niobium heavy ions on 17 structural parameters of the mouse small intestine.
  • To investigate the dose-dependency and localization of radiation-induced damage.
  • To understand the relationship between linear energy transfer (LET) and observed damage.

Main Methods:

  • Mice were treated with three types of heavy ions: neon, iron, and niobium.

Related Experiment Videos

  • Structural parameters of the small intestine were analyzed three days post-treatment.
  • Dose-response relationships and tissue compartment-specific effects were evaluated.

    • Main Results:

    • Niobium ion treatment showed non-standard changes, primarily in the epithelial compartment, with limited dose-dependency.
    • Neon ion irradiation resulted in the most significant damage compared to iron and niobium ions.
    • The observed damage pattern suggests that increased non-epithelial damage with rising LET is not always maintained.

    Conclusions:

    • Heavy ion radiation, particularly neon ions, induces significant structural damage in the mouse small intestine.
    • The response to heavy ion radiation is complex and not solely dependent on LET, with vascular and absorptive components playing a role.
    • Factors such as radiation type, dose, strain variation, and gastrointestinal status are critical for understanding radiation effects on multicellular organs.