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Related Experiment Videos

Development of gravity-sensing organs in altered gravity.

M L Wiederhold1, W Y Gao, J L Harrison

  • 1Department of Otolaryngology-Head & Neck Surgery, University of Texas Health Science Center, San Antonio 78284-7777, USA.

Gravitational and Space Biology Bulletin : Publication of the American Society for Gravitational and Space Biology
|June 1, 1997
PubMed
Summary

Microgravity exposure significantly enhanced otoconia development in newt larvae, leading to larger gravity-sensing organs and lasting functional changes in posture even after returning to Earth.

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Area of Science:

  • Gravitational biology
  • Developmental biology
  • Neuroscience

Background:

  • Gravity is crucial for the development of gravity-sensing organs.
  • Understanding how microgravity affects these systems is vital for space exploration.
  • Previous studies have indicated potential impacts of altered gravity on development.

Purpose of the Study:

  • To investigate the effects of microgravity and hypergravity on the development of gravity-sensing organs in newt larvae and Aplysia.
  • To determine if microgravity exposure has lasting functional consequences on vestibular system development.

Main Methods:

  • Newt larvae were reared in microgravity during the IML-2 mission.
  • Aplysia embryos and larvae were reared under hypergravity conditions (1-5 g) using a centrifuge.
Keywords:
NASA Discipline NeuroscienceNon-NASA Center

Related Experiment Videos

  • Development of otoliths and otoconia was analyzed in both species.

    • Main Results:

    • Aplysia embryos showed reduced statolith size and hypergravity led to fewer statoconia.
    • Newt larvae reared in microgravity developed nearly adult labyrinths with larger and earlier-developed aragonitic otoconia.
    • Post-flight, newt larvae exhibited larger otoconia volumes and abnormal upward head posture, persisting for months.

    Conclusions:

    • Microgravity exposure significantly enhances otoconia development in newt larvae.
    • This enhancement appears to initiate a long-lasting process continuing after return to 1-g.
    • Short-term microgravity exposure can lead to lasting functional consequences on posture and vestibular system development.