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[Adaptation of myocardial function to simulated weightlessness].

Z Yu1, L Zhang

  • 1Department of Aerospace Physiology, Fourth Military Medical University, Xi'an, China.

Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering
|June 1, 1997
PubMed
Summary

Simulated weightlessness impairs rat heart muscle function by reducing developed tension and altering contraction/relaxation times. These effects are reversible after a 2-week recovery period, indicating adaptive changes in cardiac sarcoplasmic reticulum calcium release.

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Area of Science:

  • Cardiovascular Physiology
  • Space Medicine
  • Skeletal Muscle Physiology

Context:

  • Simulated weightlessness, achieved through tail-suspension models, is crucial for understanding physiological adaptations to microgravity.
  • Myocardial function and calcium handling are key determinants of cardiac performance, particularly under stress.
  • Investigating these changes is vital for astronaut health and developing countermeasures for spaceflight.

Purpose:

  • To investigate the impact of 8-week simulated weightlessness on rat myocardial function, specifically focusing on contractile properties and sarcoplasmic reticulum calcium release.
  • To assess the reversibility of these functional changes after a 2-week recovery period.

Summary:

  • Eight-week tail-suspension in rats led to a significant decrease in developed tension and prolonged time to peak tension and half relaxation of myocardial twitch, without altering resting tension.

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  • Force-interval relationships showed altered early recovery, rest potentiation, and rest depression in tail-suspended rats compared to controls.
  • These functional deficits, including reduced calcium ion release from cardiac sarcoplasmic reticulum, were largely reversible after 2 weeks of recovery.

    • Impact:

    • Findings suggest adaptive changes in myocardial function during prolonged simulated weightlessness.
    • The study highlights the detrimental effect of simulated weightlessness on cardiac contractility and calcium handling.
    • Reversibility of these changes indicates potential for recovery and informs strategies for mitigating spaceflight-induced cardiovascular deconditioning.