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Tissue culture in microgravity.

P H Duray, S J Hatfill, N R Pellis

    Science & Medicine
    |May 1, 1997
    PubMed
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    Simulating tissue microenvironments in vitro is challenging due to the complex extracellular matrix. NASA

    Area of Science:

    • Biotechnology
    • Tissue Engineering
    • Cell Biology

    Background:

    • Simulating in vitro tissue microenvironments is difficult due to the complex and plastic nature of the extracellular matrix.
    • The extracellular matrix plays a crucial role in regulating cytoskeletal and nuclear matrix proteins.
    • Gravity can disrupt the integrity of simulated tissue microenvironments by causing component separation.

    Purpose of the Study:

    • To address challenges in simulating tissue microenvironments in vitro.
    • To evaluate the utility of a novel bioreactor for tissue culture applications.

    Main Methods:

    • Development of a double-walled rotating bioreactor by NASA engineers for space shuttle experiments.
    • Utilizing the bioreactor for in vitro tissue culture.
    Keywords:
    NASA Center JSCNASA Discipline Cell Biology

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    Main Results:

    • The rotating bioreactor effectively overcomes gravity-induced component separation.
    • The device proves useful for tissue culture both in space and on Earth.

    Conclusions:

    • The double-walled rotating bioreactor is a valuable tool for creating more accurate in vitro tissue microenvironments.
    • This technology has dual applications for space exploration and terrestrial research.