Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone tissue engineering: the role of interstitial fluid flow.

M V Hillsley1, J A Frangos

  • 1Department of Chemical Engineering, The Pennsylvania State University, University Park 16802, USA.

Biotechnology and Bioengineering
|March 25, 1994
PubMed
Summary

Interstitial fluid flow (ISF) is crucial for bone healing and maintenance. Reduced ISF flow, seen in conditions like bedrest, can lead to bone loss, highlighting its role in bone remodeling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methods to isolate, culture, and study osteoblasts.

Methods in molecular medicine·2011
Same author

Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain.

Antimicrobial agents and chemotherapy·2011
Same author

Pressure gradients and transport in the murine femur upon hindlimb suspension.

Bone·2006
Same author

Introduction: mechanotransduction and translational medicine workshop.

Journal of internal medicine·2006
Same author

COX-2 is necessary for venous ligation-mediated bone adaptation in mice.

Bone·2005
Same author

PECAM-1 interacts with nitric oxide synthase in human endothelial cells: implication for flow-induced nitric oxide synthase activation.

Arteriosclerosis, thrombosis, and vascular biology·2004

Area of Science:

  • Biomedical Engineering
  • Skeletal Biology
  • Fluid Dynamics

Background:

  • Vascularization is essential for bone healing, implying the necessity of blood and interstitial fluid (ISF) flow.
  • Changes in bone blood flow and ISF flow correlate with bone remodeling and formation.
  • ISF flow is driven by pressure gradients from vascular, hydrostatic, and mechanical loading factors.

Purpose of the Study:

  • To review interstitial fluid flow in bone.
  • To elucidate the role of ISF flow in osteogenesis (bone formation).

Main Methods:

  • Literature review of studies on bone blood flow and ISF flow.
  • Analysis of conditions affecting ISF flow rates and their impact on bone remodeling.
  • Examination of the hypothesis that ISF flow mediates signal transduction in bone remodeling.
Keywords:
NASA Discipline Cell BiologyNon-NASA Center

Related Experiment Videos

Main Results:

  • Altered ISF flow rates are observed in conditions such as hypertension, bedrest, microgravity, injury response, and exercise.
  • These conditions also induce changes in bone remodeling.
  • Hypothesized that ISF flow, particularly fluid shear stress, mediates remodeling signals.

Conclusions:

  • ISF flow is integral to bone healing, maintenance, and remodeling.
  • Decreased ISF flow is linked to bone loss in disuse and microgravity.
  • Understanding ISF flow mechanics is key to addressing bone loss conditions.