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Related Concept Videos

Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent – the...

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Related Experiment Video

Updated: May 19, 2026

Protein Crystallization for X-ray Crystallography
09:27

Protein Crystallization for X-ray Crystallography

Published on: January 16, 2011

Protein crystallization in microgravity.

S Aibara1, K Shibata, Y Morita

  • 1Research Institute for Food Science, Kyoto University. aibara@food.food.kyoto-u.ac.jp

Uchu Seibutsu Kagaku
|September 7, 2001
PubMed
Summary

Space experiments utilizing microgravity successfully grew high-quality protein crystals, including hen egg-white lysozyme. This research explores microgravity

Area of Science:

  • Space Science
  • Biophysics
  • Crystallography

Background:

  • Protein crystallization is crucial for determining protein structures.
  • Microgravity offers a unique environment to overcome crystallization challenges.
  • Previous space missions have explored protein crystal growth.

Purpose of the Study:

  • To investigate the effects of microgravity on protein crystal growth.
  • To obtain high-quality protein crystals for structural analysis.
  • To evaluate the feasibility of space-based protein crystallization.

Main Methods:

  • Protein crystallization experiments conducted in microgravity aboard the space shuttle Endeavour (STS-47).
  • Batch crystallization method used for five selected protein samples.

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Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies

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Related Experiment Videos

Last Updated: May 19, 2026

Protein Crystallization for X-ray Crystallography
09:27

Protein Crystallization for X-ray Crystallography

Published on: January 16, 2011

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies
12:38

Crystallization of Proteins on Chip by Microdialysis for In Situ X-ray Diffraction Studies

Published on: April 11, 2021

  • Analysis of crystal quality and diffraction properties.

    • Main Results:

    • Obtained single crystals of hen egg-white lysozyme and pyruvate aminotransferase with good diffraction quality.
    • Demonstrated the effectiveness of microgravity for growing high-quality protein crystals.
    • Established a foundation for subsequent space experiments in protein crystallization.

    Conclusions:

    • Microgravity significantly enhances protein crystal growth quality.
    • Space-based protein crystallization is a viable method for obtaining diffraction-quality crystals.
    • Further research in microgravity can advance structural biology and drug discovery.