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Updated: Aug 15, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Multistep modeling (MSM) of biomolecular structure application to the A-G mispair in the B-DNA environment
S Srinivasan1, G Raghunathan, M Shibata
1Unit of Theoretical Biology, Roswell Park Memorial Institute, Buffalo, NY 14263, USA.
Abstract:
A multistep modeling procedure has been evolved to study the structural changes introduced by lesions in DNA. We report here the change in the structure of regular B-DNA geometry due to the incorporation of Ganti-Aanti mispair in place of a regular G-C pair, preserving the helix continuity. The energetics of the structure so obtained is compared with the Ganti-Asyn configuration under similar constrained conditions. We present the methodology adopted and discuss the results.
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