Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gardner's syndrome.

A L Watne, S K Core, J M Carrier

    Surgery, Gynecology & Obstetrics
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Gardner's syndrome, an inherited condition, significantly increases intestinal cancer risk with low survival rates. Surgical intervention showed potential for polyp regression in some patients.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inhibition of oxygen release by anoxia in a C3-plant (Nicotiana tabacum cv. Wisconsin 38). Comparison with C4-plants.

    Planta·2014
    Same author

    Participants in urban Mexican male homosexual encounters.

    Archives of sexual behavior·2013
    Same author

    Evelyn Hooker: a life remembered.

    Journal of homosexuality·1998
    Same author

    Colon polyps.

    Journal of surgical oncology·1997
    Same author

    Eosinophilic colitis presenting as a left-sided colocolonic intussusception with secondary large bowel obstruction: an uncommon entity with a rare presentation.

    The American surgeon·1997
    Same author

    Small bowel carcinoid: review of a single institution experience and review of the literature.

    The American surgeon·1996

    Area of Science:

    • Genetics
    • Oncology
    • Gastroenterology

    Background:

    • Gardner's syndrome is a significant inherited disorder.
    • It is characterized by numerous gastrointestinal polyps and extracolonic manifestations.

    Purpose of the Study:

    • To investigate the clinical manifestations of Gardner's syndrome.
    • To assess the inheritance patterns and cancer risks associated with the syndrome.

    Main Methods:

    • Studied 280 patients from 11 families with Gardner's syndrome.
    • Analyzed clinical data on inherited risk, cancer development, and treatment outcomes.

    Main Results:

    • 45% of at-risk patients inherited Gardner's syndrome.
    • Intestinal carcinoma developed in 41 patients (27% survival rate).
  • Other cancers included ampullary, liver, bladder, ovarian, and osteogenic sarcoma; peritoneal fibrosis was also observed.

    • Conclusions:

    • Gardner's syndrome presents diverse clinical manifestations and significant cancer risks.
    • Colectomy and ileoproctostomy may lead to polyp regression in the rectum.