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Changes in the amino acid code.

T H Jukes1

  • 1Space Sciences Laboratory, University of California, Berkeley 94720, USA.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1983
PubMed
Summary

The genetic code

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The genetic code's structure is based on wobble-pairing between codons and anticodons.
  • The universal genetic code was once believed to be the sole code used by terrestrial life.

Purpose of the Study:

  • To explore the possibility of earlier genetic codes with fewer amino acids.
  • To investigate the relationship between mitochondrial codes and the universal genetic code.

Main Methods:

  • Analysis of codon-anticodon interactions and wobble-pairing rules.
  • Comparison of the universal genetic code with known mitochondrial coding systems.

Main Results:

  • Mitochondrial coding systems exhibit variations from the universal genetic code.
  • Mitochondrial codes also display differences among themselves.

Conclusions:

  • The existence of diverse mitochondrial codes supports the hypothesis of preceding archetypal genetic codes.
  • These ancient archetypal codes may have shared characteristics with current mitochondrial codes.

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