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[Protective effect of RenShen compound and DanHuang compound on muscle atrophy in suspended rats]
Objective:
To study the protective effect of RenShen compound and DanHuang compound on muscle atrophy caused by simulated weightlessness in rats.
Method:
Percentage and cross sectional area of fibers and ultrastructure of soleus (SOL) and gastrocnemius (GAS) were determined in 30 d tail suspended rats with or without administration of the medicine.
Result:
The percentage of type I fiber of SOL in RenShen (RS) group and DanHuang (DH) group increased by (13.5 +/- 0.96)% (P < 0.05) and (11.2 +/- 0.84)% (P < 0.05) respectively, and those of GAS showed only an increasing trend as compared with suspension control (SC). Cross sectional area of muscle fibers of SOL and GAS in both groups increased, especially in RS group (P < 0.05). The construction of SOL sarcomere in RS and DH groups was improved as compared with SC.
Conclusion:
RS and DH compounds can partially prevent muscle atrophy caused by tail suspension.