Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Changes in cerebral circulation function during head down bed rest for 7 days].

D Wang1, Q Xiang, X Shen

  • 1Institute of Space Medico-Engineering, Beijing, China.

Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering
|September 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA.

Biochemistry·1998
Same author

Chemosignal transduction in the vomeronasal organ of garter snakes: cloning of a gene encoding adenylate cyclase from the vomeronasal organ of garter snakes.

Archives of biochemistry and biophysics·1998
Same author

Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.

Journal of natural products·1998
Same author

A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-like protein-C alpha: structure and expression.

Endocrinology·1998
Same author

Pharmacokinetics and biodistribution of radioimmunoconjugates of anti-CD19 antibody and single-chain Fv for treatment of human B-cell malignancy.

Cancer immunology, immunotherapy : CII·1998
Same author

Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor.

The Journal of biological chemistry·1998
Same journal

[Citation analysis of Space Medicine & Medical Engineering].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
Same journal

[Prevention of Rhodiola-astragalus membranaceus compounds against simulated plateau hypoxia brain injury in rat].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
Same journal

[Design of software for fluorescence microscopy system to measure cytosolic free calcium in living cell].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
Same journal

[Effect of oxygen-increased respirator on SaO2 and heart rate under plateau environment].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
Same journal

[Experimental study of pilots' scan and performance, workloads].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
Same journal

[Quantitative ultrasonic naked gene delivery and the effect control].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering·2005
See all related articles

Head down bed rest (HDT) temporarily increases cerebral blood flow velocity in young men. This brain circulation change was most pronounced within 24 hours and showed a fluctuating pattern during the 7-day study period.

Area of Science:

  • Neuroscience
  • Cardiovascular Physiology

Context:

  • Understanding the physiological effects of altered body posture is crucial for spaceflight and clinical settings.
  • Short-term head down bed rest (HDT) simulates microgravity conditions, impacting fluid shifts and cardiovascular regulation.
  • Cerebral blood flow regulation is vital for maintaining brain function during postural changes.

Purpose:

  • To investigate the dynamic changes in cerebral blood flow velocity during and after a 7-day period of -6 degrees head down bed rest (HDT).
  • To analyze the temporal response of middle cerebral artery blood flow velocity to sustained head-down tilt in healthy young adults.
  • To provide insights into the regulation of brain circulation under simulated microgravity conditions.

Summary:

  • Six healthy young men (19-21 years) underwent 7 days of -6 degrees HDT.

Related Experiment Videos

  • Transcranial Doppler (TCD) measurements revealed an initial increase in middle cerebral artery blood flow velocity, peaking within the first 24 hours.
  • Velocity then decreased, reaching its lowest point on day 5, followed by a trend of increase on days 6 and 7, with symmetrical changes observed in both hemispheres.

    • Impact:

    • Findings contribute to understanding cerebrovascular adaptation to unloading conditions.
    • Provides data for developing countermeasures against potential neurological effects of spaceflight or prolonged bed rest.
    • Highlights the dynamic and adaptive nature of cerebral blood flow regulation in response to simulated microgravity.