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Related Experiment Videos

[Effect of single alpha-particle on cells].

Z Wei1, H D Pross

  • 1Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.

Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering
|September 7, 2001
PubMed
Summary

Charged particles can inactivate yeast cells, with inactivation extending beyond the direct particle path. Multiple particle hits are likely needed to kill a cell, but some inactivation occurs even with near misses.

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Area of Science:

  • Astrobiology
  • Radiation Biology
  • Cell Biology

Background:

  • Understanding the biological effects of charged particles is crucial for space exploration and radiation protection.
  • Previous studies have focused on high-density particle effects, but low-density particle interactions remain less understood.

Purpose of the Study:

  • To investigate the biological impact of low-density charged particles on eukaryotic cells.
  • To determine the relationship between alpha-particle impact parameters and yeast cell inactivation.
  • To elucidate the mechanisms of cell inactivation by charged particles.

Main Methods:

  • Utilized a microbeam facility with an alpha-radioactive source and a CN track detector.
  • Employed diploid wild type Saccharomyces cerevisiae as the experimental eukaryotic cell model.
  • Employed a CCD-camera system to correlate cell inactivation with alpha-particle impact parameters.

Main Results:

  • The inactivation range of 1.13 MeV/u alpha-particles on a cell-agarose mixture was approximately 5.5 micrometers.
  • This inactivation range exceeded the combined radius of the ion track-penumbra and the yeast cell (approx. 3.1 micrometers).
  • Observed cell inactivation rates ranged from 0.36 to 0.33, suggesting multi-hit events are necessary for cell death.

Conclusions:

  • Charged particle inactivation effects can extend beyond the direct particle trajectory.
  • Multiple particle interactions (multi-hit) are likely required for complete cell inactivation.
  • Non-zero inactivation rates were observed even when particles missed the cell, indicating indirect effects or bystander responses.

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