Biotransformation of organophosphorus compounds
Related Experiment Video
Updated: Oct 4, 2026

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants
Published on: December 22, 2023
1Department of Toxicology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Yugoslavia. mikatox@hotmail.com
Abstract:
This study reviews current understanding of mechanisms of biotransformation of organophosphorus compounds (OPC). The first part of this article covers chemical aspects of biotransformation describing reactions that lead to activation or detoxication of OPC. The second part explains biochemical mechanisms of biotransformation describing the role of enzymes that are involved in this process. Among them are the enzymes that take part in metabolic activation of OPC such as cytochrome P450 system, NADPH-cytochrome P450 reductase and flavin-containing monooxygenases. Among enzymes participating in detoxication of OPC, the role of phosphoric triester hydrolases, carboxylesterases and glutathione redox system is explained. This article also deals with other aspects of detoxication of OPC such as protein binding and the role of tissue depots for these compounds.
Related Concept Videos
Drug Biotransformation: Overview
Drug Biotransformation: Overview
Microbial Bioremediation of Pesticides
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Phase I Oxidative Reactions: Overview
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
