A novel cytotoxic flavonoid glycoside from Physalis angulata
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1College of Pharmacy, University of Houston, 4800 Calhoun, Houston, TX 77204-5515, USA. nargisi@hotmail.com
Fitoterapia
|September 7, 2001
Abstract:
A new flavonol glycoside, myricetin 3-O-neohesperidoside (1) was isolated from a cytotoxic MeOH extract of the leaves of Physalis angulata. Compound 1 showed remarkable cytotoxicity in vitro against murine leukemia cell line P-388, epidermoid carcinoma of the nasopharynx KB-16 cells, and lung adenocarcinoma A-549 with ED(50) values of 0.048, 0.50 and 0.55 microg ml(-1), respectively.
