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Antibacterial activity of Rhizophora mangle bark
G Melchor1, M Armenteros, O Fernández
1Pharmacology and Toxicology Group, National Center of Animal and Plant Health (CENSA), Carretera de Tapaste y Autopista Nacional, Apartado 10, San José de las Lajas, La Habana, Cuba. gmelchor@id.censa.edu.cu
Fitoterapia
|September 7, 2001
Summary
The aqueous extract from Rhizophora mangle bark effectively inhibited the growth of seven common wound-infecting bacteria. This natural compound shows potential for developing new antimicrobial treatments for infected wounds.
Area of Science:
- Pharmacology
- Microbiology
- Natural Product Chemistry
Background:
- Infected wounds pose a significant clinical challenge.
- There is a continuous need for novel antimicrobial agents.
- Natural products are a promising source for drug discovery.
Purpose of the Study:
- To evaluate the antimicrobial activity of Rhizophora mangle bark extract.
- To assess the stability of the formulated extract.
- To identify potential applications in wound infection treatment.
Main Methods:
- Preparation of an aqueous extract from Rhizophora mangle bark.
- Formulation of the extract to ensure physical and chemical stability.
- In vitro testing against seven common bacterial species found in infected wounds.
Main Results:
- The aqueous extract demonstrated significant inhibitory effects on bacterial growth.
- All seven tested bacterial strains were susceptible to the extract.
- The formulation maintained extract stability.
Conclusions:
- Rhizophora mangle bark extract possesses potent antimicrobial properties against key wound pathogens.
- The stable formulation suggests feasibility for therapeutic development.
- This extract is a promising candidate for novel wound infection therapies.