Related Experiment Videos
FKBPs: at the crossroads of folding and transduction
Y Harrar1, C Bellini, J D Faure
1Laboratoire de Biologie Cellulaire, INRA Versailles, 78026 Versailles Cedex, France.
Trends in Plant Science
|September 7, 2001
Abstract:
FK506-binding proteins (FKBPs) belong to the large family of peptidyl-prolyl cis-trans isomerases, which are known to be involved in many cellular processes, such as cell signalling, protein trafficking and transcription. FKBPs associate into protein complexes, although the involvement and precise role of their foldase activity remain to be elucidated. FKBPs represent a large gene family in plants that is involved in growth and development. Disruption of genes encoding FKBPs in plants and animals has underlined the importance of this family of proteins in the regulation of cell division and differentiation.