Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Viruses and interferons.

G C Sen1

  • 1Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. seng@ccf.org

Annual Review of Microbiology
|September 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses.

Current topics in microbiology and immunology·2007
Same author

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.

Apoptosis : an international journal on programmed cell death·2003
Same author

Organizations and promoter analyses of the human and the mouse genes for PACT, the protein-activator of the interferon-induced protein kinase, PKR.

Gene·2001
Same author

A comprehensive view of regulation of gene expression by double-stranded RNA-mediated cell signaling.

The Journal of biological chemistry·2001
Same author

A specific isozyme of 2'-5' oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family.

The Journal of biological chemistry·2001
Same author

Modular structure of PACT: distinct domains for binding and activating PKR.

Molecular and cellular biology·2001
Same journal

Circadian Control of Host-Microbiome Symbioses.

Annual review of microbiology·2026
Same journal

Host-Pathogen Interactions in Malaria: Invasion, Neutralization, and Evasion.

Annual review of microbiology·2026
Same journal

From an Interest in Molecules to a Fascination with Microbes.

Annual review of microbiology·2026
Same journal

Bacterial Physiology in the Context of Algal Partners.

Annual review of microbiology·2026
Same journal

Introduction.

Annual review of microbiology·2025
Same journal

Decoding Microbial Community Assembly: Insights on Vectors of Infectious Diseases.

Annual review of microbiology·2025
See all related articles

The interferon system provides crucial antiviral defense by inducing proteins that halt virus spread, though some viruses evolve to evade this innate immunity. This intricate balance regulates viral replication in mammals.

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • The interferon system is a primary defense against viral infections in mammals.
  • Interferons are cytokines with antiviral effects and profound impacts on cell physiology.
  • Their actions are mediated by hundreds of interferon-induced proteins activated via Jak-STAT pathways.

Purpose of the Study:

  • To elucidate the mechanisms and regulation of the interferon system.
  • To understand the interplay between interferons, viruses, and cellular responses.
  • To explore viral evasion strategies against interferon-mediated immunity.

Main Methods:

  • Analysis of interferon-induced protein synthesis and activation.
  • Investigation of Jak-STAT signaling pathways in response to interferons.

Related Experiment Videos

  • Examination of viral mechanisms for evading interferon responses.
  • Study of direct induction of interferon-stimulated genes by viruses and double-stranded RNA.

    • Main Results:

    • Interferons induce hundreds of proteins, many via Jak-STAT pathways, to combat viral spread.
    • Some interferon-stimulated genes are also directly induced by viral components like double-stranded RNA.
    • Certain interferon-induced proteins possess novel biochemical properties or require viral RNA for activation.
    • Viruses have evolved diverse strategies to counteract interferon synthesis and action.

    Conclusions:

    • Interferons and viruses engage in a dynamic equilibrium, regulating viral replication.
    • Understanding interferon-induced proteins and viral evasion is key to controlling viral infections.
    • The interferon system's complexity highlights its critical role in innate immunity.