Related Experiment Video
Updated: Jul 26, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Heparin-induced hepatotoxicity
K A AL-Mekhaizeem1, A H Sherker
1Division of Gastroenterology, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada.
Abstract:
Heparin-induced hepatotoxicity is well described in the literature, but rarely recognized clinically. Two cases were recently encountered. In the first case, elevated aminotransferase levels occurred after four days of heparin therapy. In the second case, enzyme levels increased after only 8 h of heparin treatment. To the authors' knowledge, this short time interval between the administration of heparin and liver enzyme elevations has not been described. The objective of this report is to increase the clinical awareness of this interesting and under-recognized biochemical observation.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Drug Toxicity: Allergic Reactions
Drug toxicity: Idiosyncratic Reactions
Venous Thrombosis III: Interprofessional Care

