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A new injectable bone substitute combining poly(epsilon-caprolactone) microparticles with biphasic calcium phosphate
P Iooss1, A M Le Ray, G Grimandi
1Laboratoire de Pharmacie Galénique, Faculté de Pharmacie de Nantes, France.
Biomaterials
|September 8, 2001
Summary
This study developed a novel injectable bone substitute (IBS) using poly(epsilon-caprolactone) microparticles for controlled drug delivery. The triphasic IBS demonstrated potential for drug delivery systems with osteoconduction properties.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Orthopaedic Engineering
Background:
- Injectable bone substitutes (IBS) are crucial for bone regeneration.
- Encapsulating therapeutic agents in microparticles protects drugs and controls release.
- Poly(epsilon-caprolactone) is a biocompatible and resorbable polymer suitable for medical applications.
Purpose of the Study:
- To develop and characterize a novel triphasic injectable bone substitute (IBS) incorporating poly(epsilon-caprolactone) microparticles for drug delivery.
- To evaluate the effect of microparticle incorporation on the rheological properties and injectability of the IBS.
- To assess the potential of the triphasic IBS as a drug delivery system with osteoconductive properties.
Main Methods:
- Poly(epsilon-caprolactone) microparticles (80-200 microm) were fabricated using a solvent evaporation-extraction process.
- Microparticles were incorporated into a biphasic calcium phosphate/hydroxypropyl methylcellulose gel IBS at varying concentrations (5-50% V/V).
- Injectability was assessed using texture analysis, and rheological properties were compared to the reference IBS.
Main Results:
- The triphasic IBS maintained rheological properties similar to the reference IBS when microparticle concentration was below 45% (V/V).
- Injectability significantly decreased with microparticle concentrations exceeding 45% (V/V).
- Preliminary in vitro studies indicated the potential of this triphasic IBS for drug delivery with osteoconduction.
Conclusions:
- Poly(epsilon-caprolactone) microparticles can be incorporated into biphasic calcium phosphate-based IBS for potential drug delivery applications.
- The concentration of microparticles critically influences the injectability and rheological properties of the composite IBS.
- This triphasic IBS shows promise as a dual-function material for bone regeneration and controlled therapeutic agent delivery.