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Dendritic cell vaccines for cancer therapy
G M Sprinzl1, L Kacani, A Schrott-Fischer
1Department of Otorhinolaryngology, Head and Neck Surgery, University of Innsbruck, Austria. georg.sprinzl@uibk.ac.at
Cancer Treatment Reviews
|September 8, 2001
Abstract:
Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the initiation of immune response. Based on the finding that the immune system usually fails to identify and kill cancer cells, DC have been recently used as vaccines for stimulation of tumour-specific immunity. This review focuses on pitfalls related to DC-based vaccination against solid tumours and on improvement of this immunotherapeutic approach for routine treatment of cancer disease.