Heterosynaptic LTP in early development
Related Experiment Video
Updated: Oct 4, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
1Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
The formation of precise synaptic connections in the developing central nervous system involves activity-dependent control of synaptic strength. Correlated activity between the afferent input and postsynaptic neuron strengthens connections through long-term potentiation (LTP), while uncorrelated synaptic inputs are selectively diminished. In this issue of Neuron, Tao et al. report that LTP in young animals has less synaptic specificity than in older animals, indicating that the properties of LTP change during development.
More Related Videos
11:13Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
Published on: November 29, 2013
14:57Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Related Concept Videos
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Postsynaptic Potential (PSP)
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Integration of Synaptic Events