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Related Experiment Videos

Effect of glutamine supplementation on exercise-induced changes in lymphocyte function.

K Krzywkowski1, E W Petersen, K Ostrowski

  • 1Copenhagen Muscle Research Centre and Department of Infectious Diseases, Rigshospitalet, 2200 Copenhagen N, Denmark.

American Journal of Physiology. Cell Physiology
|September 8, 2001
PubMed
Summary

This study found that glutamine supplements did not prevent exercise-induced changes in immune cells like lymphocytes and natural killer cells. Glutamine did not impact immune function despite altering plasma glutamine levels post-exercise.

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Area of Science:

  • Exercise immunology
  • Nutritional science
  • Cellular immunology

Background:

  • Intense exercise can temporarily impair immune function, particularly lymphocyte activity.
  • Glutamine, an amino acid, is hypothesized to play a role in mitigating exercise-induced immune suppression.
  • Understanding immune responses to exercise is crucial for athletes and immune health research.

Purpose of the Study:

  • To investigate the potential role of glutamine supplementation in preventing exercise-induced changes in lymphocyte function.
  • To examine the effects of glutamine on various immune cell populations and functions following strenuous exercise.

Main Methods:

  • A randomized, placebo-controlled, double-blind crossover study involving ten male athletes.
  • Participants underwent 2 hours of bicycle exercise at 75% maximum oxygen consumption.

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  • Glutamine or placebo was administered orally during and after exercise, with comprehensive immune cell analysis.

    • Main Results:

    • Exercise transiently increased total lymphocyte counts, including T cells and natural killer (NK) cells, with specific changes in CD8+, CD4+, and memory T cell subsets.
    • Most lymphocyte subpopulations decreased 2 hours post-exercise.
    • Glutamine supplementation maintained plasma glutamine levels but did not alter lymphocyte trafficking, immune cell activity, T cell proliferation, or key hormone/metabolite levels.

    Conclusions:

    • Glutamine supplementation does not appear to play a mechanistic role in preventing exercise-induced immune alterations in athletes.
    • The study suggests that glutamine's hypothesized role in exercise immunology may be limited.
    • Further research is needed to fully elucidate the complex relationship between nutrition and exercise-induced immune responses.