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Urapidil does not prevent postanesthetic shivering: a dose-ranging study.

S N Piper1, M T Fent, K D Röhm

  • 1Department of Anesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany. wolfang_maleck@hotmail.com

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|September 8, 2001
PubMed
Summary

Urapidil did not effectively prevent postanesthetic shivering in patients undergoing surgery. Prophylactic clonidine, however, significantly reduced shivering incidence and the need for anti-shivering therapy.

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Postanesthetic shivering is a common complication following general anesthesia.
  • Effective pharmacological interventions are crucial for patient comfort and safety.

Purpose of the Study:

  • To evaluate the efficacy of urapidil at different doses (0.2, 0.3, 0.4 mg/kg) in preventing postanesthetic shivering.
  • To compare urapidil's effect with clonidine and placebo.

Main Methods:

  • A double-blind, randomized controlled trial involving 150 patients (ASA I-III) undergoing elective surgery.
  • Patients were allocated to receive urapidil (three dose groups), clonidine (3 µg/kg), or saline placebo.
  • Postanesthetic shivering was assessed using a five-point scale.

Main Results:

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  • Urapidil did not significantly reduce the incidence or severity of postanesthetic shivering compared to placebo.
  • Clonidine significantly decreased shivering and the need for anti-shivering therapy.
  • No significant hemodynamic adverse events were observed in any group.

Conclusions:

  • Urapidil is not effective in preventing postanesthetic shivering at the doses studied.
  • Clonidine demonstrates prophylactic efficacy against postanesthetic shivering.