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Intrathecal baclofen for spastic hypertonia from stroke.

J M Meythaler1, S Guin-Renfroe, R C Brunner

  • 1Department of Physical Medicine and Rehabilitation, Division of Neurological Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, USA. JMeythal@uab.edu

Stroke
|September 8, 2001
PubMed
Summary
This summary is machine-generated.

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Continuous intrathecal baclofen infusion effectively reduces spastic hypertonia in stroke survivors. This treatment offers a sustained reduction in spasticity, improving patient outcomes.

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Pharmacology

Background:

  • Stroke is a leading cause of long-term disability, often resulting in spastic hypertonia.
  • Spasticity significantly impacts motor function and quality of life in stroke survivors.

Purpose of the Study:

  • To evaluate the efficacy of continuous intrathecal baclofen infusion for managing stroke-induced spastic hypertonia.
  • To assess the long-term effects of intrathecal baclofen therapy on spasticity.

Main Methods:

  • A randomized, double-blind, placebo-controlled crossover study was conducted.
  • Patients received either intrathecal baclofen or placebo, followed by continuous intrathecal baclofen pump implantation for eligible participants.
  • Spasticity was assessed using Ashworth and Penn spasm frequency scores over 12 months.

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Main Results:

  • Intrathecal baclofen significantly reduced lower and upper extremity spasticity scores compared to placebo at 6 hours.
  • Continuous infusion over 12 months demonstrated sustained reductions in spastic hypertonia.
  • The average effective dose for continuous intrathecal baclofen infusion was 268 microgram/day.

Conclusions:

  • Continuous intrathecal baclofen infusion is an effective method for reducing and maintaining reduced spastic hypertonia post-stroke.
  • This therapy offers a viable long-term solution for managing debilitating spasticity in stroke survivors.