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CD4 T cell surface CCR5 density as a host factor in HIV-1 disease progression.
J Reynes1, P Portales, M Segondy
1Service des Maladies Infectieuses et Tropicales, Hôpital Gui de Chauliac, Montpellier, France.
AIDS (London, England)
|September 8, 2001
Summary
Lower CCR5 density on CD4 T cells correlates with slower HIV-1 disease progression. This finding suggests CCR5 density may predict disease outcome and highlights potential therapeutic targets for HIV infection.
Area of Science:
- Immunology
- Virology
- Genetics
Background:
- CCR5 density on CD4 T cells correlates with HIV-1 viral load.
- Viral load is a key predictor of HIV-1 disease progression.
Purpose of the Study:
- To investigate the correlation between CCR5 density and HIV-1 disease progression.
- To determine if CCR5 density can serve as a prognostic marker for HIV-1 infection.
Main Methods:
- Quantitative flow cytometry was used to measure CCR5 density on CD4 T cells in HIV-1-infected adults and healthy controls.
- CCR5 genotype, including the Delta 32 deletion, was determined for all participants.
Main Results:
- CCR5 density on non-activated CD4 T cells remained stable over time in HIV-1-infected individuals.
- A significant correlation was found between CCR5 density and the CD4 T cell slope in asymptomatic, non-treated HIV-1 patients (P = 0.026).
- Slow progressors exhibited lower CCR5 densities compared to non-slow progressors and healthy controls (P = 0.004 and P = 0.002, respectively).
Conclusions:
- CCR5 density influences in-vivo HIV production and the rate of CD4 T cell decline.
- Quantifying CCR5 density may offer a novel prognostic tool for managing HIV-1 infection.
- Therapeutic strategies aimed at reducing functional CCR5 density show promise for HIV treatment.