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Related Experiment Video

Updated: Jul 22, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Hepatic dysfunction associated with moderate ovarian hyperstimulation syndrome. A case report.

K Elter¹, B Scoccia, L R Nelson

¹Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago, USA.

The Journal of Reproductive Medicine

|September 8, 2001

Summary

Liver dysfunction can occur in moderate ovarian hyperstimulation syndrome (OHSS), not just severe cases. Monitoring liver function and progesterone is crucial even in less severe OHSS presentations.

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Area of Science:

Reproductive Endocrinology
Hepatology

Background:

Liver dysfunction is a rare complication of severe ovarian hyperstimulation syndrome (OHSS).
Literature review identified only one previous case of liver dysfunction with moderate OHSS.
This case represents the first report of moderate OHSS with first-trimester progesterone levels exceeding normal third-trimester ranges.

Observation:

A 33-year-old nulligravida with infertility history presented with moderate OHSS 11 days post-embryo transfer during her fourth IVF/intracytoplasmic sperm injection cycle.
The patient was managed as an outpatient.
Significantly elevated serum progesterone and liver enzymes were noted, which is atypical for moderate OHSS.

Findings:

Hepatic dysfunction is not exclusively associated with severe OHSS.
Elevated serum progesterone levels were observed, higher than typical for moderate OHSS.
Elevated liver enzymes indicated hepatic involvement.

Implications:

Liver function should be assessed in patients with moderate OHSS.
Further research is required to elucidate the role of elevated liver enzymes and progesterone in OHSS pathogenesis.
This case highlights the importance of comprehensive monitoring in assisted reproductive technology outcomes.