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Updated: Jul 22, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

The role of inflammation in the development of chronic lung disease in neonates

J J De Dooy1, L M Mahieu, H P Van Bever

  • 1Department of Paediatrics, University Hospital of Antwerp, Belgium. jozef.dedooy@uia.ua.ac.be

European Journal of Pediatrics
|September 8, 2001
PubMed

Insights

Inflammation is critical in neonatal chronic lung disease (CLD). Early anti-inflammatory therapy may prevent CLD, but more research is needed to identify high-risk infants.

Area of Science:

  • Neonatal Medicine
  • Pulmonology
  • Immunology

Background:

  • Chronic lung disease (CLD) in neonates is linked to chorioamnionitis and Ureaplasma urealyticum colonization.
  • Inflammation is increasingly recognized as a key factor in the early development of CLD.
  • Failure to regulate inflammatory responses may cause ongoing lung damage in premature infants.

Purpose of the Study:

  • To review evidence on the role of inflammation in neonatal CLD.
  • To explore potential therapeutic strategies targeting inflammation.
  • To highlight areas requiring further research.

Main Methods:

  • Literature review of studies on neonatal CLD pathogenesis.
  • Analysis of the role of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-8) and anti-inflammatory cytokine (IL-10).
  • Evaluation of potential interventions and modulating factors.

Main Results:

  • Pro-inflammatory cytokines like IL-8 are crucial in lung inflammation.
  • Preterm infants may have impaired ability to activate the anti-inflammatory cytokine IL-10.
  • Early anti-inflammatory therapy is a potential strategy for CLD prevention, though prophylactic dexamethasone is not yet recommended.

Conclusions:

  • The precise inflammatory pathways in CLD pathogenesis require further elucidation.
  • Identifying preterm infants at highest risk for CLD is essential for targeted interventions.
  • Further research is needed on the complex, multifactorial nature of CLD.
Abstract

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