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[Impaired interferon status in children with acute respiratory infection and its correction with

E A Lykova1, A A Vorob'ev, A G Bokovoĭ

  • 1Central Clinical Hospital of the Head Office of the President of the Russian Federation, Moscow, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|September 11, 2001
PubMed

Insights

This study investigated interferon status in children with acute respiratory virus infections (ARVI). Bifidumbacterin forte, a probiotic, was found to positively regulate the interferon system in these patients.

Area of Science:

  • Immunology
  • Pediatrics
  • Microbiology

Background:

  • Acute respiratory virus infections (ARVI) significantly impact the immune system.
  • Interferon status is a key indicator of immune response in viral infections.
  • Vegetovascular dystonia serves as a comparison group for immune system evaluation.

Purpose of the Study:

  • To assess interferon status in hospitalized children with complicated ARVI.
  • To evaluate the regulatory effect of Bifidumbacterin forte on the interferon system.
  • To determine the safety and efficacy of Bifidumbacterin forte for correcting interferon status.

Main Methods:

  • Studied interferon status in 46 hospitalized children (33 with ARVI, 13 controls).
  • Administered high doses of Bifidumbacterin forte (probiotic) to ARVI patients.
  • Monitored changes in alpha-interferon, gamma-interferon, and serum interferon levels.

Main Results:

  • Significant alterations in the interferon system were observed in children with ARVI.
  • Bifidumbacterin forte enhanced alpha- and gamma-interferon induction.
  • Bifidumbacterin forte decreased serum interferon production.
  • The probiotic preparation was well-tolerated in high doses.

Conclusions:

  • Bifidumbacterin forte demonstrates a regulatory effect on the interferon system in pediatric ARVI.
  • High-dose Bifidumbacterin forte can be used to correct interferon status in children with respiratory infections.
  • Probiotic intervention shows promise for immune modulation during viral infections.

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