Related Experiment Video

Updated: Oct 4, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
08:38

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

[Microscopic polyangiitis]

V Rabrenovic, Z Kovacevic, D Jovanovic

    Vojnosanitetski Pregled
    |September 11, 2001
    PubMed

    Insights

    Microscopic polyangiitis, a rare vasculitis, involves small blood vessels and is indicated by anti-myeloperoxidase ANCA. Early detection of complications like agranulocytosis during treatment is crucial for patient survival.

    Area of Science:

    • Internal Medicine
    • Immunology
    • Nephrology

    Background:

    • Microscopic polyangiitis (MPA) is a rare systemic vasculitis affecting small blood vessels, primarily in the kidneys and lungs.
    • Anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) are key serological markers for MPA diagnosis.
    • MPA commonly presents with pulmonary hemorrhage and rapidly progressive glomerulonephritis.

    Observation:

    • A patient with MPA presented with significant lung bleeding and rapidly progressive glomerulonephritis.
    • Treatment initiated with prednisone and cyclophosphamide achieved clinical-laboratory remission.

    Findings:

    • Despite initial remission, the patient developed agranulocytosis during immunosuppressive therapy.
    • Delayed recognition of agranulocytosis led to undertreatment of subsequent pneumonia.

    Implications:

    • This case highlights the critical need for vigilant monitoring of leukocyte counts during immunosuppressive treatment for MPA.
    • Prompt management of treatment-induced complications, such as agranulocytosis, is essential to prevent fatal outcomes.
    • Understanding MPA's potential complications is vital for optimizing patient care and improving prognosis.

    More Related Videos

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis10:33

    Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

    Published on: December 17, 2021

    Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes10:46

    Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

    Published on: October 7, 2018

    Related Concept Videos

    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
    Peripheral Artery Disease I: Introduction01:30

    Peripheral Artery Disease I: Introduction

    Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
    Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

    Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

    Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...