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Significance of interferon-gamma in coronary artery bypass surgery
S J Alrawi1, A A Abo Deeb, M Samee
1Department of Surgery, Research Institute of MMC & LMC, Maimonides Medical Center, Brooklyn, New York 11219, USA.
Background:
Gamma interferon (IFN-gamma) is produced by activated natural killer and T cells under pathologic circumstances. The objective of our study was to compare the level of IFN-gamma in open and endoscopic methods of vein harvesting for coronary artery bypass surgery (CABG).
Method:
Ninety samples of human saphenous veins harvested from patients prepared for CABG. Pre- and post-procedure sera of the patients, in addition to supernatants of 3-day endothelial cell culture, were analyzed for IFN-gamma.
Results:
The mean preoperative IFN-gamma level (0.09+/-0.03 pg/mL) and that for postoperative sera (0.08+/-0.02 pg/mL) were not significantly different (P = 0.2). The mean IFN-gamma level in endothelial cell culture from the endoscopic (0.18+/-0.21 pg/mL) and the open method (0.19+/-0.39 pg/mL) were not significant (P = 0.89).
Conclusion:
We recommend the endoscopic method of vein harvesting because of its lower morbidity and earlier hospital discharge.
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