Related Experiment Videos
Molecular model for the binary complex of uropepsin and pepstatin
W F de Azevedo1, F Canduri, V Fadel
1Departamento de Física, IBILCE, UNESP, São José do Rio Preto, SP 15054-000, Brazil.
Biochemical and Biophysical Research Communications
|September 11, 2001
Abstract:
The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta-sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed.