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A selective inhibitor of Escherichia coli prephenate dehydratase
1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Bioorganic & Medicinal Chemistry Letters
|September 11, 2001
Abstract:
To identify selective prephenate dehydratase (PDT) inhibitors, a series of substituted biphenic acid derivatives was synthesized using the Ullmann reaction. Screening experiments identified 18 as a promising new PDT inhibitor.