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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Atrial natriuretic hormone, vessel dilator, long-acting natriuretic hormone, and kaliuretic hormone decrease the
D L Vesely1, G I San Miguel, I Hassan
1Division of Cardiology, Department of Internal Medicine, University of South Florida Health Sciences Center, Tampa, Florida 33612, USA. vesely.david_l@tampa.va.gov
The Journal of Clinical Endocrinology and Metabolism
|September 11, 2001
Summary
Four atrial natriuretic peptides significantly reduced corticotropin-releasing hormone (CRH), ACTH, and cortisol levels in healthy humans. These peptides may form a feedback system regulating cortisol concentrations.
Area of Science:
- Endocrinology
- Cardiovascular Physiology
Background:
- Atrial natriuretic peptides (ANPs) are involved in cardiovascular regulation.
- The hypothalamic-pituitary-adrenal (HPA) axis regulates stress response and cortisol production.
- Interactions between ANPs and the HPA axis are not fully understood.
Purpose of the Study:
- To investigate the effects of specific ANP fragments on CRH, ACTH, and cortisol levels in humans.
- To explore the potential role of ANPs in regulating the HPA axis.
Main Methods:
- Healthy human subjects (n=30) received infusions of four ANP fragments: long-acting natriuretic hormone (1-30), vessel dilator (31-67), kaliuretic hormone (79-98), and atrial natriuretic hormone (99-126).
- Circulating concentrations of CRH, ACTH, and cortisol were measured before, during, and after infusions.
- Infusions were administered at 100 ng/kg body weight/min for 60 minutes.
Main Results:
- All four ANP fragments significantly decreased circulating CRH concentrations (62-84%, P < 0.001).
- Vessel dilator, kaliuretic hormone, and long-acting natriuretic hormone markedly reduced ACTH (58-81%, P < 0.001).
- All ANP fragments lowered cortisol levels (67-73%, P < 0.001), with effects lasting 1.5-3 hours post-infusion.
Conclusions:
- Specific ANP fragments effectively decrease CRH, ACTH, and cortisol in healthy individuals.
- These findings suggest ANPs may participate in a feedback loop regulating cortisol via modulation of CRH and ACTH.
- Further research is warranted to elucidate the precise mechanisms of ANP-HPA axis interaction.
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