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Related Experiment Videos

The acute leptin response to GH.

C A Lissett1, P E Clayton, S M Shalet

  • 1Department of Endocrinology, Christie Hospital, Manchester, United Kingdom M20 4BX.

The Journal of Clinical Endocrinology and Metabolism
|September 11, 2001
PubMed
Summary
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Growth hormone (GH) significantly impacts serum leptin levels in healthy individuals, increasing them initially and then decreasing them. Factors like gender, fat mass, insulin, and age influence these GH-induced leptin changes.

Area of Science:

  • Endocrinology
  • Metabolism
  • Human Physiology

Background:

  • The acute effects of growth hormone (GH) on serum leptin levels and influencing factors are not well-understood.
  • Leptin, a key adipokine, regulates energy balance and interacts with various hormones.

Purpose of the Study:

  • To investigate the impact of acute GH administration on serum leptin levels in healthy individuals.
  • To identify factors that modulate the GH-induced changes in leptin.

Main Methods:

  • Seventeen healthy volunteers received three single doses of GH (0.27, 0.67, and 7 mg) in a randomized order.
  • Serum leptin, insulin, and IGF-I levels were measured at multiple time points post-GH administration.
  • Bioimpedance analysis was used to assess body composition (fat and lean mass).

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Main Results:

  • GH administration (0.67 and 7 mg) significantly elevated serum leptin levels at 24 hours, followed by a decrease at 72 hours.
  • Baseline and peak leptin levels were influenced by gender, fat mass, and insulin levels.
  • The increase in leptin levels was positively correlated with age, suggesting increased adipocyte responsiveness to GH in older individuals.

Conclusions:

  • Acute GH administration significantly alters circulating leptin levels in healthy individuals, independent of changes in body composition.
  • Gender, fat mass, insulin, and age are significant determinants of GH's effect on leptin.
  • The observed biphasic leptin response suggests a potential negative feedback loop regulating leptin biosynthesis.