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Boron therapeutics on the horizon
1Pharmaceutical Discovery Division, SRI International, Menlo Park, CA, USA. michael.groziak@sri.com
American Journal of Therapeutics
|September 11, 2001
Summary
Novel bioactive boron compounds are emerging as promising chemotherapeutics. This review highlights boron-based agents, including boronic acids and heterocycles, showing potential in various therapeutic areas.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Biochemistry
Background:
- Boron is an underutilized element in drug development.
- Recent advancements have yielded novel bioactive boron compounds.
- These compounds show significant therapeutic potential.
Purpose of the Study:
- To review the biological and physiological properties of boron.
- To detail emerging boron-based chemotherapeutic agents.
- To inform clinicians about the benefits of boron compounds.
Main Methods:
- Literature review of boron compounds in medicinal chemistry.
- Analysis of preclinical and clinical development of boron-based agents.
- Focus on specific classes like boronic acids and boron heterocycles.
Main Results:
- Boron compounds demonstrate efficacy as proteasome inhibitors.
- Boron agents show promise as beta-lactamase and dipeptidyl peptidase inhibitors.
- Applications include antibacterials, antiestrogens, and inositol trisphosphate receptor modulators.
Conclusions:
- Boron-based drugs are nearing market entry.
- These compounds offer unique therapeutic benefits.
- Further development is expected to expand the clinical use of boron agents.