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Related Experiment Videos

MR perfusion imaging using encapsulated laser-polarized 3He.

V Callot1, E Canet, J Brochot

  • 1Laboratoire de RMN, CNRS UMR 5012, Université Lyon 1, CPE, Villeurbanne, France.

Magnetic Resonance in Medicine
|September 11, 2001
PubMed
Summary

Researchers developed novel lipid-based helium microbubbles for intravascular laser-polarized 3He imaging. This new carrier agent enables in vivo studies, visualizing lung perfusion and defects with high signal-to-noise ratio images.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Nuclear Magnetic Resonance (NMR)

Background:

  • Intravascular laser-polarized 3He imaging requires effective carrier agents for in vivo applications.
  • Previous methods faced limitations in achieving sufficient resolution and signal for dynamic vascular imaging.

Purpose of the Study:

  • To introduce and evaluate novel lipid-based helium microbubbles as a carrier agent for intravascular laser-polarized 3He imaging.
  • To assess the feasibility of in vivo imaging of helium microbubbles in the vasculature and their potential for lung perfusion assessment.

Main Methods:

  • Synthesis and characterization of lipid-based helium microbubbles with an average diameter of 3 micrometers.
  • Measurement of NMR relaxation parameters (T1, T2, T2*) of the microbubble suspension.

Related Experiment Videos

  • Acquisition of in vivo dynamic cardiac and vascular images of encapsulated 3He in rats via intravenous injection.

    • Main Results:

    • Successfully acquired in vivo images of encapsulated 3He with signal-to-noise ratios exceeding 30.
    • Demonstrated excellent preservation of 3He polarization through lung capillaries and heart cavities.
    • Obtained the first images of 3He microbubble distribution in the lungs and visualized perfusion defects in an experimental embolism model.

    Conclusions:

    • Lipid-based helium microbubbles are a viable carrier agent for intravascular laser-polarized 3He imaging.
    • The technique allows for high-quality in vivo imaging of microbubble distribution and holds promise for lung perfusion assessment.