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Hypothalamo-pituitary-adrenal function following subarachnoid hemorrhage
Acta Neurologica Scandinavica
|July 1, 1975
Summary
Subarachnoid hemorrhage can disrupt endocrine function, particularly hypothalamo-pituitary-adrenal axes. However, severe hypopituitarism is uncommon more than 3.5 months post-hemorrhage.
Area of Science:
- Endocrinology
- Neuroscience
Background:
- Subarachnoid hemorrhage (SAH) is a critical neurological event.
- Endocrine dysfunction can be a complication following SAH.
Purpose of the Study:
- To evaluate the endocrine function in patients after subarachnoid hemorrhage.
- To assess hypothalamo-pituitary-adrenal (HPA) axis, thyroid, and gonadal functions.
Main Methods:
- Assessed HPA axis via plasma 11-hydroxycorticosteroids circadian rhythm and metyrapone testing.
- Employed screening methods for thyroid and gonadal function evaluation.
- Study included 50 patients at least 3.5 months post-SAH.
Main Results:
- Evidence suggests potential for HPA axis disturbances after SAH.
- Screening indicated possible alterations in thyroid and gonadal functions.
- No cases of overt hypopituitarism were observed in the long-term follow-up.
Conclusions:
- HPA axis dysfunction is a potential sequela of subarachnoid hemorrhage.
- While disturbances can occur, severe hypopituitarism is rare in long-term survivors.
- Further investigation into specific endocrine deficits post-SAH is warranted.