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[TT virus].

E B Zhirbut1, A V Golubeva

  • 1Blood and Tissue Center of the Military Medical Academy, St. Petersburg, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|September 12, 2001
PubMed
Summary

Transfusion-transmitted virus (TTV) is a non-enveloped virus with single-stranded DNA, potentially linked to hepatitis. Its transmission primarily occurs via the oral-fecal route, not sexual or injection methods.

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Area of Science:

  • Virology
  • Hepatology

Context:

  • TT virus (TTV) is a non-enveloped virus identified in 1997.
  • TTV possesses single-stranded circular DNA (approx. 3,800 nucleotides) and is proposed as a member of the Circinoviridae family.
  • Prevalence data for TTV is highly variable, ranging from 1-22% in blood donors, 20-40% in hematological patients, and 15-35% in liver disease patients.

Purpose:

  • To review the current understanding of TT virus (TTV) epidemiology, transmission, and pathogenicity.
  • To highlight the controversial prevalence rates of TTV in various patient groups.
  • To identify gaps in knowledge regarding TTV infection.

Summary:

  • TTV is transmitted via the oral-fecal route, entering the gastrointestinal tract and being excreted in feces through bile.
  • The low prevalence in at-risk groups suggests sexual and injection routes are not primary transmission pathways.
  • Further research is needed to clarify TTV epidemiology, pathogenicity, and diagnostic methods for TTV-associated hepatitis.

Impact:

  • This review underscores the need for comprehensive epidemiological studies on TTV.
  • It emphasizes the importance of developing accurate diagnostic tools for TTV infections.
  • Understanding TTV transmission is crucial for public health and transfusion safety.

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