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Plasma tocopherol levels correlate positively with age in children. Children with cystic fibrosis or coeliac disease often exhibit significantly lower vitamin E levels compared to healthy peers.
Area of Science:
- Pediatric Nutrition
- Gastroenterology
- Biochemistry
Background:
- Plasma tocopherol (vitamin E) is crucial for health.
- Intestinal abnormalities can impact nutrient absorption.
- Understanding vitamin E status in pediatric populations is important.
Purpose of the Study:
- To investigate plasma tocopherol concentrations in healthy children.
- To compare vitamin E levels in children with intestinal disorders versus controls.
- To determine the relationship between age and plasma tocopherol in children.
Main Methods:
- Plasma samples were collected from normal children and those with intestinal abnormalities.
- Tocopherol concentrations were measured using biochemical assays.
- Data were analyzed to assess correlations with age and disease status.
Main Results:
- A positive correlation was observed between plasma tocopherol and age in children aged 4 months to 10 years.
- Children with cystic fibrosis or coeliac disease showed markedly reduced plasma tocopherol concentrations.
- Significant differences in vitamin E status were found between patient groups and healthy children.
Conclusions:
- Age is a significant factor influencing plasma tocopherol levels in children.
- Cystic fibrosis and coeliac disease are associated with impaired vitamin E status.
- Monitoring vitamin E levels is recommended for children with these intestinal conditions.
Abstract:
A study has been made of plasma tocopherol concentrations in normal children and in children with intestinal abnormalities. A positive correlation between plasma tocopherol and age is shown between the ages of 4 months and 10 years. Most patients with cystic fibrosis or coeliac disease were found to have markedly reduced plasma tocopherol concentrations in comparison with the normal children of similar age.