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The MEROPS database as a protease information system.

A J Barrett1, N D Rawlings, E A O'Brien

  • 1Molecular Enzymology Laboratory, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom.

Journal of Structural Biology
|September 12, 2001
PubMed
Summary
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The MEROPS database classifies peptidases (proteases) by structural and sequence similarities, organizing vast biological and medical information. This resource aids research by integrating data on peptidase families, clans, and their relevance across species.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Peptidases (proteases) are crucial in biology, medicine, and biotechnology.
  • An integrated information source for peptidases is needed due to their importance.

Purpose of the Study:

  • To present the MEROPS database as a comprehensive resource for peptidase classification and information.
  • To detail the classification system based on structural and sequence homology.

Main Methods:

  • Classification of peptidases into families based on amino acid sequence homology.
  • Assembly of families into clans using evidence of common ancestry, often supported by tertiary structure similarities.
  • Utilizing secondary structure profiles for future classification refinement.

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Main Results:

  • The MEROPS database organizes peptidases by structural and sequence-based classification (families and clans).
  • It integrates diverse data including 3D structures, gene symbols, biomedical relevance, and literature links.
  • Provides species-specific peptidase lists, distribution data, and functional information like chromosomal location and substrate specificity.

Conclusions:

  • The MEROPS database provides a robust framework for understanding peptidase diversity and function.
  • It serves as an invaluable, integrated resource for researchers in various scientific disciplines.
  • The classification system facilitates access to comprehensive and interconnected peptidase data.