Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

IL-18 in patients with multiple sclerosis.

J Losy¹, A Niezgoda

¹Department of Clinical Neuroimmunology, University School of Medicine, 60-355 Poznañ, Przybyszewskiego 49, Poland.

Acta Neurologica Scandinavica

|September 12, 2001

Summary

Interleukin-18 (IL-18) levels are elevated in multiple sclerosis (MS) patients. Higher IL-18 in cerebrospinal fluid and serum indicates active disease stages and suggests its role in MS immunopathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From end-of-life tires to storable energy carriers.

Journal of environmental management·2020

Same author

IgG subclasses and their intrathecal synthesis in patients with amyotrophic lateral sclerosis.

European journal of neurology·2011

Same author

The associations between iL-18 serum levels and the prevalence of metabolic syndrome in Polish men over the age of 40 according to other selected inflammatory indices and androgens: comparison of NCEP with IDF criteria.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2011

Same author

PECAM-1, a key player in neuroinflammation.

European journal of neurology·2006

Same author

The level of chemokine CXCL5 in the cerebrospinal fluid is increased during the first 24 hours of ischaemic stroke and correlates with the size of early brain damage.

Folia morphologica·2006

Same author

Interleukin-18 in acute ischaemic stroke patients.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2003

Area of Science:

Neuroimmunology
Cytokine research

Background:

Interleukin-18 (IL-18) is a key cytokine in T-helper 1 (Th-1) immune responses.
IL-18 promotes interferon-gamma (IFN-gamma) production in T cells and natural killer (NK) cells.

Purpose of the Study:

To quantify IL-18 levels in serum and cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (MS).
To compare IL-18 levels between MS patients with and without active MRI lesions.
To compare MS patient IL-18 levels with a control group.

Main Methods:

Enzyme-linked immunosorbent assay (ELISA) was used to measure IL-18 concentrations.
Study included 21 MS patients (9 active lesions, 12 inactive lesions) and 11 controls (neurasthenia/tension headache).

Main Results:

Significantly increased IL-18 levels in both CSF and serum of MS patients compared to controls.
MS patients with active MRI lesions exhibited higher CSF and serum IL-18 levels than those without active lesions.

Conclusions:

IL-18 is implicated in the immunopathogenesis of multiple sclerosis.
Elevated IL-18 levels are particularly associated with active stages of MS.

Related Experiment Videos