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Antiglaucoma medication and clinical depression.

I Schweitzer1, K Maguire, V Tuckwell

  • 1Department of Psychiatry, The Melbourne Clinic, University of Melbourne, 130 Church Street, Richmond, Victoria 3121, Australia. i.schweitzer@medicine.unimelb.edu.au

The Australian and New Zealand Journal of Psychiatry
|September 12, 2001
PubMed
Summary

Antiglaucoma medications, particularly topical beta-blockers, may increase the risk of clinical depression. This association is often overlooked by healthcare professionals, necessitating greater awareness.

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Area of Science:

  • Ophthalmology
  • Psychiatry
  • Pharmacology

Background:

  • Glaucoma is a progressive optic neuropathy often treated with topical medications.
  • Systemic side effects of topical antiglaucoma drugs are a recognized concern.
  • Clinical depression is a potential, though often unrecognized, adverse effect.

Observation:

  • This paper reviews literature on systemic side effects of topical antiglaucoma drugs and their link to depression.
  • Two cases of clinical depression developing after using topical betaxolol are presented.
  • Depression resolved only after discontinuing betaxolol and switching glaucoma treatment.

Findings:

  • Case reports and literature suggest a link between topical ophthalmic beta-adrenoceptor antagonists and depression.

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  • The incidence of depression associated with these medications may be higher than commonly perceived.
  • This adverse effect remains poorly recognized across medical specialties.

    • Implications:

    • Increased medical awareness of this potential side effect is crucial.
    • Ophthalmologists and general practitioners should consider medication review in patients presenting with depression.
    • Further research is warranted to elucidate the mechanisms and prevalence of this association.