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Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide

R D Delmanto1, P L de Lima, M M Sugui

  • 1Departamento de Patologia, Faculdade de Medicina, UNESP, 18618-000, SP, Botucatu, Brazil.

Mutation Research
|September 12, 2001
PubMed

Insights

Agaricus blazei Murrill mushroom extracts demonstrated antimutagenic properties in vivo. A mixture of mushroom lineages inhibited cyclophosphamide-induced micronuclei formation in mice, suggesting a role in cancer prevention.

Area of Science:

  • Mycology
  • Toxicology
  • Immunology

Background:

  • Agaricus blazei Murrill extracts show anticarcinogenic and antimutagenic potential.
  • Antimutagenic activity may contribute to the anticarcinogenic effects of A. blazei, alongside immune system modulation.

Purpose of the Study:

  • To investigate the in vivo antimutagenic effect of A. blazei.
  • To evaluate the impact of A. blazei on cyclophosphamide (CP)-induced clastogenicity in mice.

Main Methods:

  • Male Swiss mice were treated with cyclophosphamide (CP) alone or with CP plus A. blazei mushroom solution at varying temperatures (4, 21, 60°C).
  • The micronucleus test in bone marrow (MNPCE) and peripheral blood (MNRET) was used to assess clastogenicity.

Main Results:

  • An aqueous solution of a mixture of A. blazei lineages inhibited CP-induced micronuclei formation in both bone marrow and peripheral blood.
  • A single isolated lineage of A. blazei did not reduce CP-induced micronuclei frequencies.

Conclusions:

  • A. blazei exhibits in vivo antimutagenic activity, particularly when using a mixture of lineages.
  • This antimutagenic effect may contribute to the observed anticarcinogenic properties of A. blazei under specific conditions.

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