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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

Insulins today and beyond.

D R Owens1, B Zinman, G B Bolli

  • 1Diabetes Research Unit, Llandough Hospital, Penlan Road, Wales CF64 2XX, Penarth, UK. owensdr@cf.ac.uk

Lancet (London, England)
|September 12, 2001
PubMed
Summary
This summary is machine-generated.

Insulin therapy has transformed diabetes care, emphasizing near-normal blood sugar control to prevent complications. Advancements in insulin delivery and glucose monitoring enhance treatment for type 1 and type 2 diabetes.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Insulin's introduction revolutionized diabetes treatment, marking a major medical advancement.
  • Growing understanding highlights the importance of near-normoglycemia for delaying diabetic complications.
  • Physiological insulin replacement is crucial for patients with insufficient endogenous insulin production.

Purpose of the Study:

  • To review the evolution and current state of insulin therapy in diabetes management.
  • To emphasize the necessity of aggressive insulin replacement strategies.
  • To highlight the role of glucose-sensing technologies in optimizing insulin therapy.

Main Methods:

  • Review of historical and current insulin treatment strategies.
  • Discussion of advancements in insulin formulations and delivery methods.
  • Integration of glucose-sensing technologies in diabetes management.

Main Results:

  • Insulin therapy has significantly improved diabetes outcomes over the past 80 years.
  • Near-normoglycemia is increasingly recognized as a key therapeutic goal.
  • Modern insulin replacement requires more aggressive approaches for both type 1 and type 2 diabetes.
  • Developments in glucose monitoring are vital for safe and effective insulin therapy.

Conclusions:

  • Insulin remains central to managing diabetes for individuals unable to produce their own.
  • Aggressive insulin therapy, coupled with advanced monitoring, is essential for optimal patient outcomes.
  • Continued innovation in insulin and glucose-sensing technology is critical for future diabetes care.