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Updated: Aug 3, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome
S J Hayflick1, J M Penzien, W Michl
1Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97201, USA.
Abstract:
Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.

