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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus
1Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. idonkor@utom.edu
Bioorganic & Medicinal Chemistry Letters
|September 12, 2001
Abstract:
The reported diketopiperazine calpain inhibitor, cis-L-L-3,6-bis-(4-hydroxybenzyl)-1,4-dimethylpiperazine-2,5-dione 1, and its analogues 3 and 4 were synthesized from the corresponding amino acids. The previously assigned structure of 1 is confirmed but neither synthetic 1 nor its N-methylphenylalanine analogues 3 and 4 inhibit porcine erythrocyte calpain I.
